Deployment is the same for Pyramid as for Pylons. Specify the desired WSGI server in the "[server:main]" and run "pserve" with it. The default server in Pyramid is Waitress, compared to PasteHTTPServer in Pylons.

Waitress' advantage is that it runs on Python 3. Its disadvantage is that it doesn't seek and destroy stuck threads like PasteHTTPServer does. If you're like me, that's enough reason not to use Waitress in production. You can switch to PasteHTTPServer or CherryPy server if you wish, or use a method like mod_wsgi that doesn't require a Python HTTP server.